Drug interactions
Ofloxacin + Parecoxib
Severity: Minor
Ofloxacin and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may add to the seizure-provoking potential of fluoroquinolones. The risk is low but is more relevant in patients with epilepsy, CNS disease or renal impairment.
What this interaction means in plain words
Ofloxacin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding, possibly enhanced by NSAIDs.
What to do
No routine adjustment is needed; avoid in patients with seizure history and monitor for CNS excitation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Parecoxib?
MediHelp rates the interaction as minor. Ofloxacin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may add to the seizure-provoking potential of fluoroquinolones. The risk is low but is more relevant in patients with epilepsy, CNS disease or renal impairment.
How serious is the interaction between Ofloxacin and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; avoid in patients with seizure history and monitor for CNS excitation.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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