Drug interactions
Ofloxacin + Polysaccharide iron
Severity: Moderate
Ofloxacin and Polysaccharide iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron preparations bind ofloxacin in the gut, which reduces its absorption and may lead to subtherapeutic antibiotic levels and treatment failure. The effect is clinically important for oral dosing of both agents.
What this interaction means in plain words
Ofloxacin and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of ofloxacin by polyvalent iron cations in the gastrointestinal tract, reducing absorption.
What to do
Give ofloxacin at least 2 hours before or 2 hours after the iron product. Avoid concurrent dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Polysaccharide iron?
MediHelp rates the interaction as moderate. Ofloxacin and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron preparations bind ofloxacin in the gut, which reduces its absorption and may lead to subtherapeutic antibiotic levels and treatment failure. The effect is clinically important for oral dosing of both agents.
How serious is the interaction between Ofloxacin and Polysaccharide iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give ofloxacin at least 2 hours before or 2 hours after the iron product. Avoid concurrent dosing.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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