Drug interactions
Ofloxacin + Promazine
Severity: Moderate
Ofloxacin and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine antipsychotic with QT-prolonging potential, and ofloxacin can also lengthen the QT interval. Together they may increase the likelihood of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Ofloxacin and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Check a baseline ECG and electrolytes, and monitor the QTc during co-therapy. Prefer a non-fluoroquinolone antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Promazine?
MediHelp rates the interaction as moderate. Ofloxacin and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine antipsychotic with QT-prolonging potential, and ofloxacin can also lengthen the QT interval. Together they may increase the likelihood of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Ofloxacin and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the QTc during co-therapy. Prefer a non-fluoroquinolone antibiotic in patients with other QT risk factors.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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