Drug interactions
Ofloxacin + Protriptyline
Severity: Moderate
Ofloxacin and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as protriptyline can prolong the QT interval, and ofloxacin has a similar although smaller effect. Using them together may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Ofloxacin and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG and correct hypokalemia and hypomagnesemia before combining. Monitor the QTc and consider an alternative antibiotic in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Protriptyline?
MediHelp rates the interaction as moderate. Ofloxacin and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as protriptyline can prolong the QT interval, and ofloxacin has a similar although smaller effect. Using them together may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Ofloxacin and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct hypokalemia and hypomagnesemia before combining. Monitor the QTc and consider an alternative antibiotic in patients with cardiac risk factors.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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