Drug interactions
Ofloxacin + Typhoid vaccine live
Severity: Moderate
Ofloxacin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is active against Salmonella Typhi and can reduce replication of the live oral typhoid vaccine strain. This may lead to inadequate immunity.
What this interaction means in plain words
Ofloxacin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces its viability.
What to do
Give oral live typhoid vaccine at least 3 days after the last ofloxacin dose, or use the inactivated injectable vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Ofloxacin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin is active against Salmonella Typhi and can reduce replication of the live oral typhoid vaccine strain. This may lead to inadequate immunity.
How serious is the interaction between Ofloxacin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral live typhoid vaccine at least 3 days after the last ofloxacin dose, or use the inactivated injectable vaccine.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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