Drug interactions
Ofloxacin + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Ofloxacin and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol can affect heart rhythm and QT interval, and ofloxacin may add QT prolongation. Inhaled systemic exposure is low, so the risk is modest but relevant in patients with cardiac risk factors.
What this interaction means in plain words
Ofloxacin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT effects, with beta-agonist-related hypokalemia and cardiac stimulation.
What to do
Monitor for palpitations and arrhythmia and check potassium in patients with cardiac risk factors. Consider an alternative antibiotic in patients with known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Ofloxacin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol can affect heart rhythm and QT interval, and ofloxacin may add QT prolongation. Inhaled systemic exposure is low, so the risk is modest but relevant in patients with cardiac risk factors.
How serious is the interaction between Ofloxacin and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia and check potassium in patients with cardiac risk factors. Consider an alternative antibiotic in patients with known QT prolongation.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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