Drug interactions
Olanzapine + Pasireotide
Severity: Moderate
Olanzapine and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and cause bradycardia, and olanzapine can also modestly prolong QT. Combined use may raise the risk of arrhythmia, especially with hypokalemia or hypomagnesemia.
What this interaction means in plain words
Olanzapine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Obtain a baseline ECG and monitor it periodically during co-treatment. Correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Olanzapine with Pasireotide?
MediHelp rates the interaction as moderate. Olanzapine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong the QT interval and cause bradycardia, and olanzapine can also modestly prolong QT. Combined use may raise the risk of arrhythmia, especially with hypokalemia or hypomagnesemia.
How serious is the interaction between Olanzapine and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically during co-treatment. Correct potassium and magnesium before and during therapy.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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