Drug interactions
Olanzapine + Pitolisant
Severity: Moderate
Olanzapine and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant prolongs the QT interval modestly, and olanzapine may add to the effect. Pitolisant is also an H3 antagonist, which may oppose the sedating effects of olanzapine.
What this interaction means in plain words
Olanzapine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus pharmacodynamic opposition at histamine receptors.
What to do
Obtain an ECG at baseline and monitor the QTc during concurrent use. Avoid the combination in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Olanzapine with Pitolisant?
MediHelp rates the interaction as moderate. Olanzapine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant prolongs the QT interval modestly, and olanzapine may add to the effect. Pitolisant is also an H3 antagonist, which may oppose the sedating effects of olanzapine.
How serious is the interaction between Olanzapine and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and monitor the QTc during concurrent use. Avoid the combination in patients with other QT risk factors.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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