Drug interactions
Olanzapine + Quinine
Severity: Moderate
Olanzapine and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have the potential to prolong the QT interval, although olanzapine's effect is generally modest. Together they may increase the risk of arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Olanzapine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities; repeat ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Quinine?
MediHelp rates the interaction as moderate. Olanzapine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have the potential to prolong the QT interval, although olanzapine's effect is generally modest. Together they may increase the risk of arrhythmia, particularly with other risk factors.
How serious is the interaction between Olanzapine and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities; repeat ECG if other QT risk factors are present.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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