Drug interactions
Olanzapine + Scopolamine
Severity: Moderate
Olanzapine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has appreciable anticholinergic activity, so adding scopolamine can increase dry mouth, constipation, urinary retention, blurred vision, sedation and confusion. Anticholinergic load is a particular concern in older patients, and heat intolerance may also be a problem.
What this interaction means in plain words
Olanzapine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade, with additive CNS depressant effects.
What to do
Monitor for anticholinergic effects, cognition and bowel function, and limit the duration of scopolamine. Lower the dose or choose an alternative if delirium or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Scopolamine?
MediHelp rates the interaction as moderate. Olanzapine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has appreciable anticholinergic activity, so adding scopolamine can increase dry mouth, constipation, urinary retention, blurred vision, sedation and confusion. Anticholinergic load is a particular concern in older patients, and heat intolerance may also be a problem.
How serious is the interaction between Olanzapine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, cognition and bowel function, and limit the duration of scopolamine. Lower the dose or choose an alternative if delirium or retention develops.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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