Drug interactions
Olanzapine + Somapacitan
Severity: Minor
Olanzapine and Somapacitan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450 activity, which could lower concentrations of CYP1A2 substrates such as olanzapine. The effect is theoretical and likely small.
What this interaction means in plain words
Olanzapine and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Somapacitan belongs to Endocrine.
Why it happens
Possible growth hormone-mediated induction of CYP1A2 activity, increasing olanzapine clearance.
What to do
No empiric dose change is needed; monitor psychiatric response after starting or changing somapacitan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Olanzapine with Somapacitan?
MediHelp rates the interaction as minor. Olanzapine and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450 activity, which could lower concentrations of CYP1A2 substrates such as olanzapine. The effect is theoretical and likely small.
How serious is the interaction between Olanzapine and Somapacitan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor psychiatric response after starting or changing somapacitan.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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