Drug interactions
Olanzapine + Somatrogon
Severity: Minor
Olanzapine and Somatrogon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone products may increase the activity of some cytochrome P450 enzymes. Olanzapine is cleared largely by CYP1A2, so its concentrations could fall modestly, though the effect has not been well characterized for somatrogon.
What this interaction means in plain words
Olanzapine and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone may induce CYP-mediated metabolism, potentially increasing CYP1A2 clearance of olanzapine.
What to do
No routine dose change is needed; watch for loss of psychiatric symptom control after somatrogon is started and adjust the olanzapine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Olanzapine with Somatrogon?
MediHelp rates the interaction as minor. Olanzapine and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone products may increase the activity of some cytochrome P450 enzymes. Olanzapine is cleared largely by CYP1A2, so its concentrations could fall modestly, though the effect has not been well characterized for somatrogon.
How serious is the interaction between Olanzapine and Somatrogon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for loss of psychiatric symptom control after somatrogon is started and adjust the olanzapine dose if needed.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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