Drug interactions
Olanzapine + Zuranolone
Severity: Moderate
Olanzapine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired psychomotor performance, and olanzapine is also sedating. Together they can increase CNS depression, drowsiness and impaired driving ability.
What this interaction means in plain words
Olanzapine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression; zuranolone is a positive allosteric modulator of GABA-A receptors and olanzapine blocks histamine H1 and other receptors.
What to do
Consider reducing the zuranolone dose if sedation is excessive. Counsel patients not to drive or operate machinery for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Olanzapine with Zuranolone?
MediHelp rates the interaction as moderate. Olanzapine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired psychomotor performance, and olanzapine is also sedating. Together they can increase CNS depression, drowsiness and impaired driving ability.
How serious is the interaction between Olanzapine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if sedation is excessive. Counsel patients not to drive or operate machinery for at least 12 hours after each dose.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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