Drug interactions
Olanzapine / samidorphan + Oxazepam
Severity: Moderate
Olanzapine / samidorphan and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is sedating and can cause orthostatic hypotension, and oxazepam adds further central depression. The combination can increase drowsiness, dizziness and the risk of falls, particularly in older patients.
What this interaction means in plain words
Olanzapine / samidorphan and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects through different receptor mechanisms.
What to do
Monitor for sedation and orthostatic blood pressure changes, and use the lowest effective doses. Counsel patients to rise slowly and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine / samidorphan and Oxazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Oxazepam?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is sedating and can cause orthostatic hypotension, and oxazepam adds further central depression. The combination can increase drowsiness, dizziness and the risk of falls, particularly in older patients.
How serious is the interaction between Olanzapine / samidorphan and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic blood pressure changes, and use the lowest effective doses. Counsel patients to rise slowly and avoid alcohol.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
