Drug interactions
Olanzapine / samidorphan + Oxymorphone
Severity: Contraindicated
Olanzapine / samidorphan and Oxymorphone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Samidorphan is an opioid antagonist that blocks oxymorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Analgesia may fail.
What this interaction means in plain words
Olanzapine / samidorphan and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Pharmacodynamic antagonism at opioid receptors by samidorphan.
What to do
Do not start in patients using opioids; allow at least 7 days opioid-free for short-acting and 14 days for long-acting opioids before starting. Use another antipsychotic if opioids are needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
- Oxymorphone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Oxymorphone?
MediHelp rates the interaction as contraindicated. Olanzapine / samidorphan and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks oxymorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Analgesia may fail.
How serious is the interaction between Olanzapine / samidorphan and Oxymorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; allow at least 7 days opioid-free for short-acting and 14 days for long-acting opioids before starting. Use another antipsychotic if opioids are needed.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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