Drug interactions
Oxymorphone + Selegiline transdermal
Severity: Contraindicated
Oxymorphone and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been associated with serious reactions with opioids, including serotonin syndrome, hypotension, hyperpyrexia and CNS depression. Oxymorphone labeling advises against use with MAOIs.
What this interaction means in plain words
Oxymorphone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition may potentiate opioid effects and serotonergic or adrenergic toxicity; mechanism with oxymorphone is not fully defined.
What to do
Avoid concurrent use and for at least 14 days after stopping the MAOI. Choose an alternative analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxymorphone with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Oxymorphone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors have been associated with serious reactions with opioids, including serotonin syndrome, hypotension, hyperpyrexia and CNS depression. Oxymorphone labeling advises against use with MAOIs.
How serious is the interaction between Oxymorphone and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and for at least 14 days after stopping the MAOI. Choose an alternative analgesic.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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