Drug interactions
Olanzapine / samidorphan + Paroxetine
Severity: Moderate
Olanzapine / samidorphan and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on the CNS, and olanzapine can cause sedation and orthostatic hypotension. Adding paroxetine may increase drowsiness and dizziness, and paroxetine may modestly raise olanzapine levels. The effect is usually manageable.
What this interaction means in plain words
Olanzapine / samidorphan and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive pharmacodynamic effects; paroxetine may slightly inhibit olanzapine metabolism.
What to do
Monitor for sedation, dizziness and orthostatic blood pressure changes when starting or adjusting either drug. Counsel patients about driving and rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Paroxetine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on the CNS, and olanzapine can cause sedation and orthostatic hypotension. Adding paroxetine may increase drowsiness and dizziness, and paroxetine may modestly raise olanzapine levels. The effect is usually manageable.
How serious is the interaction between Olanzapine / samidorphan and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic blood pressure changes when starting or adjusting either drug. Counsel patients about driving and rising slowly.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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