Drug interactions
Olanzapine / samidorphan + Phenelzine
Severity: Moderate
Olanzapine / samidorphan and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine and olanzapine can both cause sedation and orthostatic hypotension, and together these effects may be amplified. Falls and dizziness are the main practical concerns, particularly in older patients.
What this interaction means in plain words
Olanzapine / samidorphan and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression and hypotensive effects (alpha-1 blockade by olanzapine, vasodilation and orthostasis from MAOI).
What to do
Monitor blood pressure including orthostatic readings and sedation when starting or adjusting either drug. Titrate gradually and counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Phenelzine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenelzine and olanzapine can both cause sedation and orthostatic hypotension, and together these effects may be amplified. Falls and dizziness are the main practical concerns, particularly in older patients.
How serious is the interaction between Olanzapine / samidorphan and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings and sedation when starting or adjusting either drug. Titrate gradually and counsel patients to rise slowly.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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