Drug interactions
Olanzapine / samidorphan + Ropinirole
Severity: Moderate
Olanzapine / samidorphan and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine blocks dopamine D2 receptors and can counteract ropinirole, potentially worsening motor symptoms in Parkinson disease. Ropinirole may in turn aggravate psychosis. The practical effect varies with the dose and the indication.
What this interaction means in plain words
Olanzapine / samidorphan and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition between D2 antagonism (olanzapine) and D2/D3 agonism (ropinirole).
What to do
Monitor motor function and psychiatric symptoms, and avoid the combination in Parkinson disease where possible. Use quetiapine or clozapine if an antipsychotic is needed in Parkinson disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Ropinirole?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine blocks dopamine D2 receptors and can counteract ropinirole, potentially worsening motor symptoms in Parkinson disease. Ropinirole may in turn aggravate psychosis. The practical effect varies with the dose and the indication.
How serious is the interaction between Olanzapine / samidorphan and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function and psychiatric symptoms, and avoid the combination in Parkinson disease where possible. Use quetiapine or clozapine if an antipsychotic is needed in Parkinson disease.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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