Drug interactions
Olanzapine / samidorphan + Sacubitril-valsartan
Severity: Moderate
Olanzapine / samidorphan and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, and this may add to the blood pressure lowering of sacubitril-valsartan. Patients may experience dizziness, light-headedness or falls, especially after starting or increasing either drug.
What this interaction means in plain words
Olanzapine / samidorphan and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects of olanzapine (alpha-1 adrenergic blockade) and the angiotensin receptor blocker/neprilysin inhibitor.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension, and this may add to the blood pressure lowering of sacubitril-valsartan. Patients may experience dizziness, light-headedness or falls, especially after starting or increasing either drug.
How serious is the interaction between Olanzapine / samidorphan and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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