Drug interactions
Olanzapine / samidorphan + Spironolactone
Severity: Moderate
Olanzapine / samidorphan and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, which may add to the blood pressure-lowering effect of spironolactone. Patients may experience dizziness, syncope or falls, particularly at treatment initiation.
What this interaction means in plain words
Olanzapine / samidorphan and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from olanzapine alpha-1 adrenergic blockade and spironolactone-induced volume reduction.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Spironolactone?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension, which may add to the blood pressure-lowering effect of spironolactone. Patients may experience dizziness, syncope or falls, particularly at treatment initiation.
How serious is the interaction between Olanzapine / samidorphan and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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