Drug interactions
Olanzapine / samidorphan + Terazosin
Severity: Moderate
Olanzapine / samidorphan and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension through alpha-1 blockade and may enhance the effect of terazosin. Patients may experience dizziness, falls or syncope.
What this interaction means in plain words
Olanzapine / samidorphan and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism by olanzapine and terazosin.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the terazosin dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Terazosin?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension through alpha-1 blockade and may enhance the effect of terazosin. Patients may experience dizziness, falls or syncope.
How serious is the interaction between Olanzapine / samidorphan and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the terazosin dose if hypotension occurs.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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