Drug interactions
Olanzapine / samidorphan + Timolol
Severity: Moderate
Olanzapine / samidorphan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, which may add to the blood pressure-lowering effect of timolol. Patients may experience dizziness, syncope, or falls, particularly when treatment is started or doses are raised.
What this interaction means in plain words
Olanzapine / samidorphan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotension from olanzapine alpha-1 adrenergic antagonism and beta-blockade.
What to do
Monitor blood pressure and orthostatic symptoms, especially during titration. Reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Timolol?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension, which may add to the blood pressure-lowering effect of timolol. Patients may experience dizziness, syncope, or falls, particularly when treatment is started or doses are raised.
How serious is the interaction between Olanzapine / samidorphan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially during titration. Reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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