Drug interactions
Olanzapine / samidorphan + Tolterodine
Severity: Moderate
Olanzapine / samidorphan and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity, which adds to the antimuscarinic effect of tolterodine. The combination can increase constipation, urinary retention, dry mouth and sedation, and in severe cases cause ileus.
What this interaction means in plain words
Olanzapine / samidorphan and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor bowel function, urinary symptoms and cognition, and treat constipation early. Reduce or stop tolterodine if significant hypomotility develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Olanzapine / samidorphan with Tolterodine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity, which adds to the antimuscarinic effect of tolterodine. The combination can increase constipation, urinary retention, dry mouth and sedation, and in severe cases cause ileus.
How serious is the interaction between Olanzapine / samidorphan and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary symptoms and cognition, and treat constipation early. Reduce or stop tolterodine if significant hypomotility develops.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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