Drug interactions
Olanzapine / samidorphan + Triamterene
Severity: Minor
Olanzapine / samidorphan and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, which may add to the blood-pressure lowering effect of diuretics such as triamterene. This can cause dizziness or falls, particularly at the start of therapy or after dose increases.
What this interaction means in plain words
Olanzapine / samidorphan and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects from olanzapine's alpha-1 adrenergic blockade and triamterene-induced volume loss.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating; reduce the diuretic dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine / samidorphan and Triamterene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Triamterene?
MediHelp rates the interaction as minor. Olanzapine / samidorphan and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine can cause orthostatic hypotension, which may add to the blood-pressure lowering effect of diuretics such as triamterene. This can cause dizziness or falls, particularly at the start of therapy or after dose increases.
How serious is the interaction between Olanzapine / samidorphan and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating; reduce the diuretic dose if hypotension occurs.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
