Drug interactions
Olanzapine / samidorphan + Trospium
Severity: Moderate
Olanzapine / samidorphan and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity, and combined with trospium it can increase the risk of reduced gut motility, constipation and in severe cases ileus. Urinary retention, dry mouth and confusion are also more likely.
What this interaction means in plain words
Olanzapine / samidorphan and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects of olanzapine and trospium.
What to do
Monitor bowel function and urinary symptoms; start a bowel regimen if constipation develops and reduce anticholinergic load where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Frequently asked questions
Can I take Olanzapine / samidorphan with Trospium?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity, and combined with trospium it can increase the risk of reduced gut motility, constipation and in severe cases ileus. Urinary retention, dry mouth and confusion are also more likely.
How serious is the interaction between Olanzapine / samidorphan and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms; start a bowel regimen if constipation develops and reduce anticholinergic load where possible.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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