Drug interactions
Olaparib + Siponimod
Severity: Moderate
Olaparib and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib can cause anemia, neutropenia and lymphopenia, and siponimod also lowers lymphocytes. Combined use may increase infection risk.
What this interaction means in plain words
Olaparib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive hematologic suppression from PARP inhibition and S1P receptor-mediated lymphocyte sequestration.
What to do
Monitor complete blood counts and infection signs; consider interrupting siponimod if marked cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Siponimod?
MediHelp rates the interaction as moderate. Olaparib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib can cause anemia, neutropenia and lymphopenia, and siponimod also lowers lymphocytes. Combined use may increase infection risk.
How serious is the interaction between Olaparib and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and infection signs; consider interrupting siponimod if marked cytopenias occur.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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