Drug interactions
Olaparib + Tocilizumab
Severity: Moderate
Olaparib and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes anaemia, neutropenia and thrombocytopenia, and tocilizumab can reduce neutrophil and platelet counts and impair infection defences. Combined use could increase the risk of cytopenias and infection.
What this interaction means in plain words
Olaparib and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Tocilizumab belongs to Musculoskeletal.
Why it happens
Additive myelosuppression and immunosuppression; no pharmacokinetic interaction is known.
What to do
Monitor complete blood counts regularly and manage infections promptly. Interrupt or reduce the dose of either drug if significant neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Tocilizumab?
MediHelp rates the interaction as moderate. Olaparib and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib commonly causes anaemia, neutropenia and thrombocytopenia, and tocilizumab can reduce neutrophil and platelet counts and impair infection defences. Combined use could increase the risk of cytopenias and infection.
How serious is the interaction between Olaparib and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and manage infections promptly. Interrupt or reduce the dose of either drug if significant neutropenia develops.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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