Drug interactions
Olaparib + Vinorelbine
Severity: Moderate
Olaparib and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function. Used together, they can cause more severe or longer-lasting neutropenia, anemia and thrombocytopenia than either alone.
What this interaction means in plain words
Olaparib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive myelosuppression from microtubule inhibition (vinorelbine) and PARP inhibition (olaparib).
What to do
Monitor complete blood counts regularly, particularly neutrophils and platelets. Reduce doses or delay treatment if significant cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Vinorelbine?
MediHelp rates the interaction as moderate. Olaparib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function. Used together, they can cause more severe or longer-lasting neutropenia, anemia and thrombocytopenia than either alone.
How serious is the interaction between Olaparib and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, particularly neutrophils and platelets. Reduce doses or delay treatment if significant cytopenias occur.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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