Drug interactions
Olmesartan + Timolol
Severity: Moderate
Olmesartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan can raise serum potassium, and beta-blockade may further reduce cellular potassium uptake, so hyperkalemia is possible in susceptible patients. Additive blood pressure lowering also occurs.
What this interaction means in plain words
Olmesartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olmesartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Reduced aldosterone-mediated potassium excretion from angiotensin receptor blockade plus impaired beta-2 mediated potassium uptake, with additive hypotension.
What to do
Monitor serum potassium, renal function and blood pressure after initiation and dose changes. Adjust therapy if hyperkalemia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Timolol?
MediHelp rates the interaction as moderate. Olmesartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan can raise serum potassium, and beta-blockade may further reduce cellular potassium uptake, so hyperkalemia is possible in susceptible patients. Additive blood pressure lowering also occurs.
How serious is the interaction between Olmesartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and blood pressure after initiation and dose changes. Adjust therapy if hyperkalemia or hypotension develops.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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