Drug interactions
Olmesartan + Tolvaptan
Severity: Moderate
Olmesartan and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is a vasopressin antagonist that causes aquaresis and has been associated with increases in serum potassium. Together with an angiotensin receptor blocker, which also reduces potassium excretion, hyperkalemia may be more likely. Rapid fluid loss may also add to hypotension.
What this interaction means in plain words
Olmesartan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olmesartan belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Additive potassium retention from ARB-mediated aldosterone reduction and tolvaptan effects, with additive volume depletion and hypotension.
What to do
Monitor serum potassium, renal function and blood pressure after starting tolvaptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olmesartan and Tolvaptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Olmesartan with Tolvaptan?
MediHelp rates the interaction as moderate. Olmesartan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan is a vasopressin antagonist that causes aquaresis and has been associated with increases in serum potassium. Together with an angiotensin receptor blocker, which also reduces potassium excretion, hyperkalemia may be more likely. Rapid fluid loss may also add to hypotension.
How serious is the interaction between Olmesartan and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and blood pressure after starting tolvaptan.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
