Drug interactions
Olodaterol inhaled + Phenelzine
Severity: Major
Olodaterol inhaled and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate the cardiovascular effects of beta2-agonists such as olodaterol, including tachycardia, palpitations, blood pressure changes and arrhythmia. Olodaterol labeling advises extreme caution with MAO inhibitors or other drugs that prolong the QT interval.
What this interaction means in plain words
Olodaterol inhaled and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic potentiation of adrenergic cardiovascular stimulation and possible additive QTc prolongation.
What to do
Avoid the combination where possible, or use only with close monitoring of heart rate, blood pressure and ECG. Consider an alternative bronchodilator such as an anticholinergic agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Olodaterol inhaled with Phenelzine?
MediHelp rates the interaction as major. Olodaterol inhaled and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors may potentiate the cardiovascular effects of beta2-agonists such as olodaterol, including tachycardia, palpitations, blood pressure changes and arrhythmia. Olodaterol labeling advises extreme caution with MAO inhibitors or other drugs that prolong the QT interval.
How serious is the interaction between Olodaterol inhaled and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use only with close monitoring of heart rate, blood pressure and ECG. Consider an alternative bronchodilator such as an anticholinergic agent.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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