Drug interactions
Olodaterol inhaled + Salmeterol
Severity: Major
Olodaterol inhaled and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are long-acting beta-2 agonists, so using them together duplicates therapy and increases tachycardia, tremor, hypokalemia and arrhythmia risk without added benefit.
What this interaction means in plain words
Olodaterol inhaled and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta-2 adrenergic receptor stimulation from duplicate long-acting agonists.
What to do
Avoid concurrent use of two long-acting beta-agonists and choose a single agent. Monitor heart rate and potassium if the overlap occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Olodaterol inhaled with Salmeterol?
MediHelp rates the interaction as major. Olodaterol inhaled and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are long-acting beta-2 agonists, so using them together duplicates therapy and increases tachycardia, tremor, hypokalemia and arrhythmia risk without added benefit.
How serious is the interaction between Olodaterol inhaled and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta-agonists and choose a single agent. Monitor heart rate and potassium if the overlap occurs.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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