Drug interactions
Olodaterol inhaled + Timolol
Severity: Major
Olodaterol inhaled and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol blocks beta-adrenergic receptors and can oppose the bronchodilating action of olodaterol, a long-acting beta-2 agonist. Nonselective beta-blockers such as timolol can also provoke bronchospasm in patients with COPD or asthma, even when given as eye drops.
What this interaction means in plain words
Olodaterol inhaled and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors, with nonselective blockade also promoting bronchoconstriction.
What to do
Avoid nonselective beta-blockers including timolol in patients who need olodaterol; if a beta-blocker is essential, choose a cardioselective agent and monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Olodaterol inhaled with Timolol?
MediHelp rates the interaction as major. Olodaterol inhaled and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Timolol blocks beta-adrenergic receptors and can oppose the bronchodilating action of olodaterol, a long-acting beta-2 agonist. Nonselective beta-blockers such as timolol can also provoke bronchospasm in patients with COPD or asthma, even when given as eye drops.
How serious is the interaction between Olodaterol inhaled and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers including timolol in patients who need olodaterol; if a beta-blocker is essential, choose a cardioselective agent and monitor respiratory symptoms and lung function.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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