Drug interactions
Olopatadine intranasal + Promethazine
Severity: Moderate
Olopatadine intranasal and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and promethazine is strongly sedating. Together they increase CNS depression and impair psychomotor performance and alertness, including next-day impairment.
What this interaction means in plain words
Olopatadine intranasal and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from central H1 receptor antagonism.
What to do
Avoid concurrent use where practical and warn the patient about driving or operating machinery. Consider a non-sedating alternative for one of the two indications.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Olopatadine intranasal with Promethazine?
MediHelp rates the interaction as moderate. Olopatadine intranasal and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, and promethazine is strongly sedating. Together they increase CNS depression and impair psychomotor performance and alertness, including next-day impairment.
How serious is the interaction between Olopatadine intranasal and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where practical and warn the patient about driving or operating machinery. Consider a non-sedating alternative for one of the two indications.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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