Drug interactions
Olopatadine intranasal + Selegiline
Severity: Minor
Olopatadine intranasal and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and systemic exposure is limited. Selegiline has minimal sedating effects, so any additive impairment is small.
What this interaction means in plain words
Olopatadine intranasal and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression.
What to do
Advise patients to watch for drowsiness before driving. No dose change is needed routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Olopatadine intranasal with Selegiline?
MediHelp rates the interaction as minor. Olopatadine intranasal and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal olopatadine can cause somnolence, and systemic exposure is limited. Selegiline has minimal sedating effects, so any additive impairment is small.
How serious is the interaction between Olopatadine intranasal and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for drowsiness before driving. No dose change is needed routinely.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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