Drug interactions
Olutasidenib + Pimozide
Severity: Moderate
Olutasidenib and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and may lower pimozide concentrations, reducing its effectiveness. Control of tics or psychosis could be lost.
What this interaction means in plain words
Olutasidenib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olutasidenib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
CYP3A4 induction by olutasidenib increases pimozide metabolism.
What to do
Avoid if possible; otherwise monitor for loss of pimozide effect and consider dose adjustment with ECG monitoring. Re-evaluate the dose when olutasidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Olutasidenib with Pimozide?
MediHelp rates the interaction as moderate. Olutasidenib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olutasidenib induces CYP3A4 and may lower pimozide concentrations, reducing its effectiveness. Control of tics or psychosis could be lost.
How serious is the interaction between Olutasidenib and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor for loss of pimozide effect and consider dose adjustment with ECG monitoring. Re-evaluate the dose when olutasidenib is stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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