Drug interactions
Omacetaxine + Trastuzumab
Severity: Moderate
Omacetaxine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omacetaxine commonly causes marked myelosuppression. Adding trastuzumab may further increase neutropenia and infection risk.
What this interaction means in plain words
Omacetaxine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts frequently, especially early in treatment. Hold or reduce omacetaxine for severe cytopenias per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Omacetaxine with Trastuzumab?
MediHelp rates the interaction as moderate. Omacetaxine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omacetaxine commonly causes marked myelosuppression. Adding trastuzumab may further increase neutropenia and infection risk.
How serious is the interaction between Omacetaxine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, especially early in treatment. Hold or reduce omacetaxine for severe cytopenias per labeling.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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