Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Oxcarbazepine
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce paritaprevir and ritonavir exposure, risking hepatitis C treatment failure.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Oxcarbazepine induces CYP3A4, increasing clearance of paritaprevir and ritonavir.
What to do
Avoid and use a non-inducing anticonvulsant or alternative HCV regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Oxcarbazepine?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine may reduce paritaprevir and ritonavir exposure, risking hepatitis C treatment failure.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid and use a non-inducing anticonvulsant or alternative HCV regimen.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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