Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Valsartan
Severity: Moderate
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paritaprevir and ritonavir inhibit hepatic transporters including OATP1B1/1B3, which may increase valsartan exposure. This raises the risk of hypotension and worsening renal function.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP-mediated hepatic uptake of valsartan by paritaprevir and ritonavir, increasing systemic exposure.
What to do
Consider a lower valsartan starting dose and monitor blood pressure and renal function. Reduce the dose further or switch to another antihypertensive if hypotension or renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Valsartan?
MediHelp rates the interaction as moderate. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paritaprevir and ritonavir inhibit hepatic transporters including OATP1B1/1B3, which may increase valsartan exposure. This raises the risk of hypotension and worsening renal function.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower valsartan starting dose and monitor blood pressure and renal function. Reduce the dose further or switch to another antihypertensive if hypotension or renal decline occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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