Drug interactions
Orphenadrine + Scopolamine
Severity: Moderate
Orphenadrine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has substantial anticholinergic activity and adds to scopolamine's antimuscarinic effects. Patients may experience dry mouth, tachycardia, urinary retention, constipation, confusion and agitation.
What this interaction means in plain words
Orphenadrine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with additional CNS depression.
What to do
Monitor for anticholinergic toxicity and cognitive impairment, particularly in elderly patients. Avoid the combination in patients with glaucoma, urinary retention or ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Orphenadrine and Scopolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Scopolamine
Frequently asked questions
Can I take Orphenadrine with Scopolamine?
MediHelp rates the interaction as moderate. Orphenadrine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has substantial anticholinergic activity and adds to scopolamine's antimuscarinic effects. Patients may experience dry mouth, tachycardia, urinary retention, constipation, confusion and agitation.
How serious is the interaction between Orphenadrine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive impairment, particularly in elderly patients. Avoid the combination in patients with glaucoma, urinary retention or ileus.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
