Drug interactions
Orphenadrine + Tolterodine
Severity: Moderate
Orphenadrine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has strong anticholinergic properties, so combining it with tolterodine increases antimuscarinic burden. This can cause dry mouth, urinary retention, constipation, confusion, blurred vision and tachycardia, especially in older adults.
What this interaction means in plain words
Orphenadrine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid the combination in older or cognitively impaired patients. Otherwise monitor for urinary retention, confusion and constipation and lower doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Orphenadrine with Tolterodine?
MediHelp rates the interaction as moderate. Orphenadrine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has strong anticholinergic properties, so combining it with tolterodine increases antimuscarinic burden. This can cause dry mouth, urinary retention, constipation, confusion, blurred vision and tachycardia, especially in older adults.
How serious is the interaction between Orphenadrine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older or cognitively impaired patients. Otherwise monitor for urinary retention, confusion and constipation and lower doses if needed.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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