Drug interactions
Oxacillin + Salsalate
Severity: Minor
Oxacillin and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate may modestly raise oxacillin exposure, since salicylates can compete for renal tubular secretion and plasma protein binding of penicillins. Clinical consequences are generally small given the wide therapeutic index of oxacillin.
What this interaction means in plain words
Oxacillin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate competes with oxacillin for renal tubular secretion and albumin binding.
What to do
No routine dose change is needed; watch for penicillin adverse effects such as rash or neurotoxicity in patients with renal impairment or high-dose therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxacillin
- Bcg vaccine live + Oxacillin Moderate
- Chloramphenicol + Oxacillin Moderate
- Cholera vaccine + Oxacillin Moderate
- Demeclocycline + Oxacillin Moderate
- Doxycycline + Oxacillin Moderate
- Microbiota + Oxacillin Moderate
Frequently asked questions
Can I take Oxacillin with Salsalate?
MediHelp rates the interaction as minor. Oxacillin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate may modestly raise oxacillin exposure, since salicylates can compete for renal tubular secretion and plasma protein binding of penicillins. Clinical consequences are generally small given the wide therapeutic index of oxacillin.
How serious is the interaction between Oxacillin and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for penicillin adverse effects such as rash or neurotoxicity in patients with renal impairment or high-dose therapy.
What other medicines interact with Oxacillin?
MediHelp also lists interactions of Oxacillin with, for example, Bcg vaccine live, Chloramphenicol, Cholera vaccine. The full list is on the Oxacillin page.
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