Drug interactions
Oxacillin + Willow bark
Severity: Minor
Oxacillin and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate, and may slightly reduce renal elimination of penicillins. The clinical effect is expected to be small.
What this interaction means in plain words
Oxacillin and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate derived from willow bark may compete with oxacillin for renal tubular secretion.
What to do
No dose adjustment is usually needed; monitor for penicillin adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxacillin
- Bcg vaccine live + Oxacillin Moderate
- Chloramphenicol + Oxacillin Moderate
- Cholera vaccine + Oxacillin Moderate
- Demeclocycline + Oxacillin Moderate
- Doxycycline + Oxacillin Moderate
- Microbiota + Oxacillin Moderate
Frequently asked questions
Can I take Oxacillin with Willow bark?
MediHelp rates the interaction as minor. Oxacillin and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylate, and may slightly reduce renal elimination of penicillins. The clinical effect is expected to be small.
How serious is the interaction between Oxacillin and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for penicillin adverse effects in patients with renal impairment.
What other medicines interact with Oxacillin?
MediHelp also lists interactions of Oxacillin with, for example, Bcg vaccine live, Chloramphenicol, Cholera vaccine. The full list is on the Oxacillin page.
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