Drug interactions
Oxazepam + Papaveretum
Severity: Major
Oxazepam and Papaveretum: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine. Concurrent use with a benzodiazepine can cause deep sedation, respiratory depression, coma and death.
What this interaction means in plain words
Oxazepam and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptor agonism and GABA-A potentiation.
What to do
Avoid unless no alternative exists; then use reduced doses and monitor respiratory rate and level of consciousness. Have resuscitation and reversal measures available in monitored settings.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Oxazepam with Papaveretum?
MediHelp rates the interaction as major. Oxazepam and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine. Concurrent use with a benzodiazepine can cause deep sedation, respiratory depression, coma and death.
How serious is the interaction between Oxazepam and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless no alternative exists; then use reduced doses and monitor respiratory rate and level of consciousness. Have resuscitation and reversal measures available in monitored settings.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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