Drug interactions
Oxazepam + Pimozide
Severity: Moderate
Oxazepam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and psychomotor slowing, which may be additive. Pimozide has additional QT-prolonging and extrapyramidal effects, though oxazepam is not known to affect these.
What this interaction means in plain words
Oxazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxazepam belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and dopamine D2 antagonism with antihistaminic effects of pimozide.
What to do
Monitor for excessive sedation and impaired coordination, and keep doses low initially. Maintain routine ECG and electrolyte monitoring for pimozide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Oxazepam with Pimozide?
MediHelp rates the interaction as moderate. Oxazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and psychomotor slowing, which may be additive. Pimozide has additional QT-prolonging and extrapyramidal effects, though oxazepam is not known to affect these.
How serious is the interaction between Oxazepam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and impaired coordination, and keep doses low initially. Maintain routine ECG and electrolyte monitoring for pimozide.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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