Drug interactions
Oxazepam + Propranolol
Severity: Minor
Oxazepam and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is not known to alter oxazepam clearance meaningfully because oxazepam is cleared by glucuronidation rather than oxidation. Any effect is expected to be small, though the two drugs may both cause fatigue or dizziness.
What this interaction means in plain words
Oxazepam and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxazepam belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Possible minor effect on oxazepam clearance; the mechanism is poorly established.
What to do
No dose adjustment is needed; monitor for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Oxazepam with Propranolol?
MediHelp rates the interaction as minor. Oxazepam and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol is not known to alter oxazepam clearance meaningfully because oxazepam is cleared by glucuronidation rather than oxidation. Any effect is expected to be small, though the two drugs may both cause fatigue or dizziness.
How serious is the interaction between Oxazepam and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for excess sedation.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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