Drug interactions
Oxazepam + Topiramate
Severity: Moderate
Oxazepam and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate can cause somnolence, psychomotor slowing and cognitive impairment, which may add to the sedative effects of oxazepam. The combination can impair alertness and driving ability.
What this interaction means in plain words
Oxazepam and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxazepam belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression via different mechanisms.
What to do
Monitor for excessive sedation and cognitive impairment, and consider lowering the oxazepam dose; counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Topiramate
Frequently asked questions
Can I take Oxazepam with Topiramate?
MediHelp rates the interaction as moderate. Oxazepam and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate can cause somnolence, psychomotor slowing and cognitive impairment, which may add to the sedative effects of oxazepam. The combination can impair alertness and driving ability.
How serious is the interaction between Oxazepam and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive impairment, and consider lowering the oxazepam dose; counsel patients about driving.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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