Drug interactions
Oxazepam + Triazolam
Severity: Major
Oxazepam and Triazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so combined use duplicates therapy and increases sedation, amnesia, impaired psychomotor function and respiratory depression.
What this interaction means in plain words
Oxazepam and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Avoid using two benzodiazepines together and consolidate to a single agent. If a switch is needed, taper gradually and monitor for oversedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Oxazepam with Triazolam?
MediHelp rates the interaction as major. Oxazepam and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are benzodiazepines, so combined use duplicates therapy and increases sedation, amnesia, impaired psychomotor function and respiratory depression.
How serious is the interaction between Oxazepam and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two benzodiazepines together and consolidate to a single agent. If a switch is needed, taper gradually and monitor for oversedation.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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