Drug interactions
Oxazepam + Yohimbine
Severity: Minor
Oxazepam and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects that may partly oppose the sedative and anxiolytic action of oxazepam. The net clinical effect is unpredictable and no firm evidence of harm exists.
What this interaction means in plain words
Oxazepam and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition between benzodiazepine GABAergic sedation and yohimbine-induced noradrenergic activation; not firmly established.
What to do
Monitor for reduced anxiolytic or hypnotic response to oxazepam, and for agitation or anxiety attributable to yohimbine. Adjust therapy based on the clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxazepam and Yohimbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Oxazepam with Yohimbine?
MediHelp rates the interaction as minor. Oxazepam and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects that may partly oppose the sedative and anxiolytic action of oxazepam. The net clinical effect is unpredictable and no firm evidence of harm exists.
How serious is the interaction between Oxazepam and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anxiolytic or hypnotic response to oxazepam, and for agitation or anxiety attributable to yohimbine. Adjust therapy based on the clinical response.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
